How can I manage difference btw UE4 and Blender?

Hi guys

I’m a newbie of 3D game programming and modelling.
In the last few months, I got used to Unreal Engine. And now I am thinking of starting a 3D modeling.

I chose Blender, because it’s free. But the way of manipulation, say, selecting and moving around, are way different from UE4. I’m very confused.

If you are using UE4 and Blender, how are you managing these differences?
Do you recommend me to configure Blender setting(*), or do you think I should stick with the original Blender manipulation? Or do I need to change setting of UE4.

(*) For example, this setting ? =>!

Thank you