Alembic is a format where you could import pre-simulated particle systems, so no it wouldn’t interact with anything, it’s already pre-simulated.
What you could do with today’s technology is that you could create a water surface that will have basic ripples when a character interacts with it (it uses displacement to create ripples and waves) then with some more complex shaders it can create some foam around rocks and other things. Besides that you can make a basic particle splash effect in certain places or for when a character walks through the water.
It’s not at all a fluid simulation but that’s the kind of thing you can get in games at the moment. To do a fluid sim you’d need to be able to simulate millions and millions of points in real-time which isn’t possible right now.