One thing is the Imported and the Max In-Game resolutions need to be exactly the same. Currently, yours is Imported: 4096 x 2048, and Max In-Game: 2048 x 2048…
Some of the other import settings aren’t showing in the last screenshot. What are those?
Have you tried changing the Projection Center value? Z=500 is rather high, and could be a part of the skewing.