Update to my own comment. NVIDIA Streamline module fights with the FSR3 FI module. Streamline is the module for Reflex and Frame Generation. r.Streamline.InitializePlugin and r.FidelityFX.FI.Enabled (and some other cvars, see the readme) must be toggled accordingly in the config before the engine starts. This is only relevant for frame generation, not upscaling, and can’t be changed during runtime. There is also a bug with r.Streamline.InitializePlugin where it is not properly working due to module initialization order, I have sent a bug report for that.
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