Failed to open descriptor file

Same thing happened for me, my solution is:

  • Backup and remove files from folder: "YourGame\Config" (It will remove all project settings)
  • Remove files from folders: “YourGame\Intermediate”, “YourGame\Saved”, “YourGame\Binaries”, “YourGame\Build”
  • Restart and rebuild project
  • Setup project settings from scratch

Done