Failed to open descriptor file on shipping build config?

Getting the same “Failed to open descriptor file” error. The build runs fine from the original directory it was built to, but the error comes up when I copy the package to a network and try to run it from there. Disabling the substance plug-in isn’t an option, as that would require major rework of the project. Any other workarounds for this issue? This error is a show stopper and we need to get the package out to the client. Thanks for any help!