Custom Characters in Lyra using Reference Pose for Hand Animations

Hi, there
Welcome to this community.
What is the skeleton rig of your custom characters? UE4 (B_TinplateUE4)? UE5 (Manny/Quinn)? Mixamo? To get the best retargeting results, please check your retargeting pose, and try to use TPose for both source and target mesh. There is a thread about this topic below: