Learn how to use the free Plugin PaperZD to improve your sprite workflow in Unreal Engine.
Easily set up animation blueprints just like you would for skeletal mesh based characters and use anim notifies to trigger events on certain frames of your animation.
https://dev.epicgames.com/community/learning/tutorials/ka9K/unreal-engine-paperzd-tutorial-2d-animation-blueprints-and-anim-notifies