I’ve had a similar problem (not sure if the same).
For me it was that I created a pawn blueprint with a sphere as the root component and the DestructibleMesh attached to it. Because I was using BlockAll as the collision on the root sphere anything but Destructible as the collision parameter on the DestructibleMesh whenever I collided with it using my character it would crash UE4.
Make sure that your DestructibleMesh is set to Destructible in it’s collisions might be the issue you’re having.
I been having the same crash issue with the destructibles. In my case the editor crashed when I start the game if there is a blueprint actor with DestructibleMesh component.
Thanks for the heads up, JamesG. Can’t wait for the fix for this issue in the coming 4.2 update!