Can't run on this system

So i was useing unreal yesterday and have been using it for god knows how many years. Today it is telling me my system can not runthis program. Nothing has changed on my system and i have not updated unreal has it is uptodate. Any help would be great, thanks.

Very interesting. Something has clearly changed or got corrupted. Which version are you using? I would probably start with trying to verify the installation or re-installing the engine.
By any chance have you updated (or auto updated) your graphics drivers?