Can you have a PC game that has an HTML5 interface?

I know this might be pretty out there, but I was wondering if you could have a PC network game, that also had an HTML 5 interface for managing elements within the game in real time ?

Any thoughts on how to go about this ?

You could use Coherent GT (Coherent Labs). It is a middleware solution that allows you to create your whole UI with HTML5/CSS/JavaScript and has an Unreal Engine 4 plugin. You can control the UI logic through Blueprints or C++.
What UI do you have in mind for your game?