animation in UE.54 Level sequence is stuttering and not usable

Hello Forum!

I have a space station project with different level sequence animations, some bink display animations, animated standard characters and 3 animated metahumans.

When adding another level sequence animation it stops and jerks as if the engine is overloaded.

However, the displayed frame rate is over 105 FPS, I have also set the texture pool size to 8 GB and still have a large reserve on my NVIDIA RTXA 4080 graphics card.

The same animation runs smoothly in an empty project.

Can or must I configure other parameters or am I reaching a limit of the engine? (The assets in the project are currently 3 GB in size?

Many thanks for some ideas and your feedback!