Animating the human hand.... where?

Hello,

my plan is to animate the human hand doing complex things like using a tool, writing, etc. I am OK with modelling and texturing, but I am a totally beginner in animation. My main 3D creation software is blender.

How would you start this task? I have a finished model of the hand with the corresponding bones ready. Would you pose the hand in blender or in UE?

Thanks a lot in advance.