I am not sure about the rest - UE4 tend to recompile the whole thing (I dont understand) when even small CPP changes are detected. So if you delete those intermediate folders you may have to rebuilt which takes a long time. I dont have time to actually experimenting.
If I were you, it is suffice to delete just PDB. In my 4.27 source compile, PDB takes about 40GB space and the whole thing is about 155GB. Maybe better invest in new SSD, they are cheap nowadays.