Activating Nanite destroys meshes

[Matrix_Moddz_PT1]

Make sure you have DirectX12 set as active.
Go to Project Settings → Platforms → Windows → Default RHI → DirectX 12.
Nanite only works if DirectX 12 is activated apparently.

Your problem seems to be equal to this one:

Huge quality loss with Nanite?

If you hover over the project name in the top right bar of the editor, it’ll tell you if you’re using DirectX 11 or DirectX 12. With 5.0 Nanite was changed to DirectX 12 only. You can also use the Nanite debug views to see if it’s working at all under the viewport lit options.

So the fix might be the same.