A way to refresh "EditorPerProjectUserSettings.ini" via Python, without restarting?

I’m changing editor preferences using an Editor Utility Widget, and am successfully able to make changes to “EditorPerProjectUserSettings.ini”.

However, even though the changes are there, Unreal isn’t loading them.

Is there a way to force Unreal to refresh/reload the INI so that the Editor Preferences take effect?

Thanks for any advice,

VF