Will a PNY Quadro P2200 5GB be enough to run Unreal Engine?

In 99.9% cases you’ll be better off with with a non-Quadro card. Are you going to drive four 5k monitors? If the answer is no, then you don’t need / want it.

The CPU / RAM / fast drive are more important for dev, unless you’re focusing on games / arch-vis exclusively. You need a beefy modern GPU to do ray tracing.

From the performance point of view, that Quado card is in the low-to-mid tier at best by today’s standard. For the price you can get a more traditional video adapter that will blow the Quadro out of the water. But you’ll be able to drive three 4k monitors only

It’s a nightmarish time for buying a GPU (reasons too numerous to mention here!); if you can get your hands on a GeForce 3060, 3070, 3080 - do that! You will not look back. The 20xx series is good, too and more easily available / aggressively priced.