What is this? A material? Widget? 9 slice scaling? GridPanel? What? What do you mean by 4x4 image? Are you talking the widget Image setting? If so, give us a screenshot of your widget’s image settings and if you’re using a material, show us that too. I’d interested in the brush settings, specifically the Image, Draw As and Tiling settings. And if you’re using a material, we’d need to see that too.
I looked at your posted image. There are some whitened rectangular areas in many places. I need more info before I can make any guesses as to why that’s happening.