This is so true; the main reason I can’t go back to UE4 is that the UI causes me metaphorical pain. (And in some cases when I have a migraine, literal pain, though I couldn’t tell you why the stripey-crosshatch pattern is an icepick to the brain in those scenarios; maybe something about the contrast or the pattern itself.)
That aside, I’d add one more thing to the various recommendations: if you’re trying to write a bunch of reusable systems as part of your project.
The project I’m working on right now does not actually require any of the UE5 features; I could almost certainly do it in UE4 (if I clenched my jaw and tolerated the UE4 editor UI, anyway). However, a bunch of the systems I’m writing are meant to be reusable in other games in the future. As such, I’m doing this project in UE5 because this way, for some future project that does need UE5, those systems will already be UE5-ready (and using UE5 features where appropriate) rather than my needing to port them over and update them.