We have lots of blueprints internally that have more than 100 nodes. It’s niceto keep things as small as possible, but no smaller 
>Will it make a difference performance-wise on runtime?
No. The details of each blueprint (either the one very large blueprint or the many smaller blueprints) will determine performance. The only thing I can say is that if you have to Tick something it is probably better to tick one large thing instead of many small things.