Hi,
unfortunately no, not at the moment. When I originally made the plugin I did not consider this use case. Mostly because the plugin was mainly supposed to help with scattering very large amounts of instances, which would cause serious hitches, when being generated at runtime. Only way to avoid that would be some sort of async system, but asynchronous computation is way beyond my current skill level.
I plan to add some BP functions to allow generating and changing the distributions at runtime, but currently the plugin doesn’t support that, and even once it does, it probably won’t be usable anywhere outside level loading time, assuming that long hitches are not tolerable in a serious game use case.