bumped into this thread experiencing problems with adjusting mesh relative location on tick when network smoothing is applied, above node shown by TheRealOzzy1 (Cache Initial Mesh Offset) does fix this, however causes issues with smoothing - workaround suggested by shark0151 to interp this seems to alleviate problem but network smoothing is still worse than normal if cache is repeatedly set (i.e. on tick)
I found better alternative to this in my case was to transform root bone of mesh in animation blueprint. Instead of setting mesh relative location, set a vector for transform offset, and use this in your animation blueprint to simply offset whole skeleton. No more issues with network smoothing, etc.