Using Item Remover Devices seems like the easiest way to remove weapons from the player’s inventory. You have the option to configure the device, for example to only remove weapons, leaving consumable items in the player’s inventory, you would set the “Affected Objects” to “Weapons”. Alternatively, you can populate the device with an array of the specific types of items you would like to remove from the player’s inventory.
The verse hooks are here: item_remover_device class | Unreal Editor for Fortnite Documentation | Epic Developer Community (epicgames.com)