How to set SButton fixed size Width and Height (not padding)?

You have to disable DPI scaling. You can do that by editing the DPI scale curve in the Project Settings > User Interface > DPI Scale Curve, set all the keys to 1, and it will never scale at any resolution.

I don’t recommend doing it though, games that have a UI that doesn’t scale across different resolutions generally have a terrible experience at anything other than the authored resolution.