How can I change 1 specific color on a sprite?

[skydashstudio]

This is a sample 2 colors sprite material. You can arrange from this.

Prepare a sprite. I use red channel represent to color 1. Green channel represent to color 2.

Create a sprite material. Use Linear interpolate to separate colors.

Create a material instance. You can change colors of this material.

Apply that material to your sprite.