Travis, I agree that it’s smart to unwrap in Mudbox/Z-Brush/Maya, rather than RC. As witnessed by many posts in this forum, UV tile allocation is often suboptimal in RC and the number of small patches created makes it difficult to paint in post.
I’m sure the community would love to see a side-by-side example of a texture tile from RC and one from your unwrapping settings in Z-Brush. If you can post a couple images I’m sure it would make the value of this clearer to many of the users who don’t have a production background in CGI.