Engine freezes when I click on "run game"

So, I’ve only worked with the Unreal Engine 5.3 for a few months, but so far it mostly went without technical problems.
But since today the Engine freezes, when I click on the button to run the game. The rest of the computer works just fine, but I can’t interact with the engine anymore and have to close it with the taskmanager.
I already tried to patch my project to the version before the crash, disabled motion blur (I read in a forum that it might help with freezing) and restarted and updated the PC.
Has anyone experienced something similar or knows where the problem could be?

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