I do. I have same Wacom Intuos tablet. Although I’m not certain that it has to be plugged in, perhaps just having drivers/software installed is enough to cause conflict. It’s hard for me to test at momment, have recently put a clean install of Windows 10 preview on my machine.
Edit: I did just test on this new Windows 10 clean installation (without installing or connecting tablet) and I’m having no freezing in UE4 log.