@sotroll - You should be fine. That function takes in a Primitive Component (even though its called Mesh) so assuming you’re using something like the Paper Sprite Component (which is a primitive component) everything should just work in theory. In practice though, this flow hasn’t been tested before, so there’s that. If you really need dynamic collision handling for your usecases, another option is to use the Infinite/Unbound Manager and thus free yourself completely from manual handling of dynamic collision. The Unbound mode is fully automatic/uncached so it picks up all dynamic changes instantly. This does make it much slower though.
Other than that, expect to spend some time on initial setup / tweaking the world grid and voxel sizes, etc. There’s a sweet spot for every project and it can take some experimentation to find the right one for yours.