We’re pretty light-weight in terms of requirements of UE4 binaries, the problems with running on the different distros so far - putting aside build-time problems with too old mono, misused gold linker or broken for some reason clang 3.4, which are applicable if you’re building from sources - were differences between window managers (not strictly a distro-specific thing). Also, for some older distros (think CentOS 6.x or Debian-stable) getting up to date graphics drivers may eventually become a problem too, depending on your hardware. The safest bet is to use latest (K)Ubuntu for development.