My guess is that the “cached derived data” really only matter when you cook for that platform, though, so if you develop on Windows and test/cook on Windows, it’s unlikely to make much of a difference.
Disabling those “support …” features are not really about content, it’s about how the renderer sets up the shaders, and may give you some cycles per pixel on low-end platforms, like intel integrated laptops, low-cost mobiles, or webgl web pages.
I’m a little worried about the report that the cached folder keeps growing as of 4.25, though. It’s totally possible there’s some kind of bug there. The good news is that you can nuke everything in that folder, and re-cooking will re-build it all for the next published version of the game.