Hello there @Toutclakos!
I have encountered this issue in other threads. Please follow these steps to resolve the issue:
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Go to your engine install location (example C:\Program Files\Epic Games\UE_5.5\Engine\Plugins\Marketplace).
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Your plugins should be here, in folders with random string of numbers and letters after
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Locate the Substance plugin folder and rename it to just “Substance”
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Restart your engine and check your materials, you may need to re-check certain features, like tessellation.
Hope this helps!