While using the Unreal Engine would be the lowest barrier for entry, you may want to take a honest look at the capabilities and functions of a program like iClone by http://www.reallusion.com which is specifically made for character animations, posing, voice integration with model faces etc. Their product stack is mature and has several components (facial voice and other character and prop mechanics etc), so you wouldn’t have to recreate the wheel. I used to use it years ago and found it suitable to what I was working on then.
I was not crazy about the iClone price model but to each their own. UE4 excels in this department in my opinion for a great well rounded tool, especially since the Sequencer animation toolset has been introduced. I love it. Currently my pipeline consists of Maya / C4D / UE4 for my mad scientist development.
I think checking out other tools that do some character oriented “Film set” production will give you a better idea on how to finally settle on a tool for your needs. In many cases you may choose UE4 and iClone, as many of us use multiple tools Maya, 3DS Max, C4D, and Blender etc…