This sounds like a really good way for things to get confusing and unwieldly but if you can manage all of this data then you can accomplish this with the Runtime DataTable plugin. DataTables built into the engine require a struct, but RDT can work with structs or any random UObject. You just have to make sure the spreadsheet’s column names and the object’s variable names are an exact match.
I’d personally recommend a separate spreadsheet for each type of object so you can easily know which variables belong to which classes, but it’s up to you. You won’t need to create a struct either way.