Hey there @Donaldk31888! So there’s a number of ways you could handle it really. You could disable visibility and collisions as Oortiz suggested. If you want to disable collisions on your actor:

However for all game actions such as loading new levels, I’d recommend having those transitions in either your level BP or your Gamemode and calling them when all of your enemies are destroyed, then you don’t have to worry about any actor containing the logic being destroyed and being unable to transition.
Hope this helps!