Yes. I would probably use the rig from UE Tools ([ADDON ] UE Tools - Community & Industry Discussion - Epic Developer Community Forums), that way you can retarget mannequin animations to your rig. You might also want to check out Prevent Blender FBX Exporter adding extra root bone – Kris Redbeard to fix extra root bones (solves issues with APEX for example). Note that if you do so you’ll have to move the IK bones in the UE Tools rig under the root in the hierarchy since they are on the same level as the root bone by default for some reason.
For me animations export and import correctly without having to change anything.