For something ‘centralised’ like this, you may want to have an Items Subsystem. Then everything that wants to access Items, will access it via this Subsystem.
The Subsystem will still a reference to the Data Asset, but it’s going to only be a single reference for your entire game.
Game Instance Subsystem sounds sufficient in this case, but in many other cases, you will typically want a World Subsystem.
Additionally, depending on how many Items you have and how much data each Item consumes, you may want to consider using Data Assets instead of a Data Table for your Items. Data Assets can be streamed in and out on a per-item basis, whereas as a Data Table must be fully loaded.