As said above, you will encounter some problems while transferring project from software rendering to real time rendering.
Also, game engines work extremely different from rendering software like mental ray or Vray and ect.
Another thing is that game engines usually use some fake or trick to balance the performance instead of achieve ultimate realism in rendering software.
The result is you will not get the same quality as rendering software provides you.
However, it is not possible and there are a lot of things you can do to make is look awesome.
Those are my opinions, I worked as architectural and interior designer since 2012.
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