Yes, and no. If you right click on the UnrealEditor icon, then go to Properties > Compatibility, and then enable Override High DPI scaling behavior, and set that to provided by application. Now, Unreal will be in the correct resolution, but depending on your monitor size, you may need to mess with the widget reflector scale setting to get things a good size for you, and unfortunately those settings seem to reset every time you close Unreal no matter what, but it only takes a few sconds to go in and enter a value you like, so I’ll take it for now, although better 4K monitor support would be nice.