[4.10.4] How can I add ',' and '.' to large numbers?

You can try using the ToText / AsCurrency nodes (if Blueprint) or FText statics (if C++).

Keep in mind that Blueprints can only handle int32 (max of ~2.7bil) or floats which might get inaccurate once you hit 8+ digits. If you use C++ you should be fine.

Alternatively, if you operate on strings, you can try something like this: