Hey Axiom,
I apologize for the delay in response here. Our compatibility lab is in the process of an overhaul and we don’t have our AMD CPU rigs hooked up yet.
In the meantime, can I get you to send the dxdiag reports for each PC? (The “Save All Information” button in dxdiag will let you save out a txt file) You can attach those to your reply to this question, no need to edit the original post.
I’d also like to know what project you’re trying to use. Is it a custom project, one of our sample projects, or a modified sample project? It sounds like you made a post on the forums, can I get that link?
It sounds like you were on UE4 version 4.5(you indicated updating to 4.6.1), is that correct? Have you tried moving to 4.7.6 or one of the 4.8 previews yet?
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EDIT: I’m also wondering if there’s any specific piece of software (antivirus, some strange USB display adapter with drivers, etc) that you’re running across all these PC’s. I ask because I run an FX 8350 at home with no issues.