When I try packaging my game that runs on UE 4.8.1, it packages fine in shipping mode, but as soon as I try to run the executable, I get the following error from a message box:
Failed to open descriptor file ‘…/…/…/GameName-Win32-Shipping/GameName-Win32-Shipping.uproject’
Edit: Development builds work, but not shipping in either 32 or 64 bit mode.