Unfortunately it made no difference.
The primary monitor was on DVI, which was number 3. Left is on display port and number 1, right on HDMI which is obviously number 2.
It’s never been an issue up until now, so my thinking is perhaps some weird windows update was done which caused the issue maybe…
Either that, or later Nvidia drivers, but still that’s not an issue as it wasn’t an issue before.
On windows 7, people said to disable Aero, that didn’t fix things either, however was the most common “fix” for people.
The odd thing about this issue (at least in my case) is every other window in Windows 7 or 10 is fine, they animate ok, but then while I was in Windows 7, it would randomly decide to stutter and the system would slow to a crawl unless I disabled Aero, even running any Origin game had issues, however The Witcher 3, Dragons Dogma, Alien Isolation, etc all ran perfectly ok.
It’s just such an inconsistent issue that it makes things very frustrating and depressing, as I have gone from 70+ hrs of game dev to …zero 
I tried a few different older Nvidia drivers too, but that didn’t fix anything sadly.