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How would I make a Npc player come to my player and shake hands??

How would I get both players to shake hands through animation?

Depends on your situation. is this an NPC that has any sort of AI? if so, the AI would be where you do that.
Otherwise you can have the animation be played by a sequence, or … there’s just way too many ways really. what is the end goal?

Yes that makes sense the end goal is to have random npc come in a store and purchase items and shake hands at the end and have AI Npc leave and other Npc arrive

Im new to using UE4 I haven’t seen any information on animations using more than one Actors or Characters at time in the animation