The software should support the TitanX just fine, and it should be better than most Quadros for viewports in Maya. For GPU rendering (Octane) gaming cards are the fastest, and you can use as many as you can plug in your computer–just make sure SLI is turned off.
Not all systems support 16GB sticks so that’s something you have to check in the motherboard stats for Max RAM. I would also think that Quad Channel would work better than Dual Channel, 4x 8GB sticks should be good. And for UE4 it’s good to have 32GB for building lighting.
Also remember as far as cases go, gaming cards run fast but they also run hot, so cooling can be an issue. That’s one reason to use Quadro since they are more reliable in the long-term.