Github build vs Binary.

What are the differences between working with the binary downloads of the unreal engine, and manual build of the Engine source from Github?

Is there difference in intellisence/configurability/others?

One difference regarding editing would be that you can jump to the implementation of things you use, and not only its declarations.

You can also build all tools and the engine itself in debug mode making debugging easier. Setting a break-point when the engine starts is also a thing you can only do when you are using sources.