There is only one persistent level and you use it when you stream levels. Correct me if I’m wrong but I think that when you say different “persistent” levels you mean normal individual levels without level streaming and the other “persistent” level is the actual persistent level with sub-scenarios.
If this is the case the answer is it depends, it’s something to test yourself to determine what works better, IMO unless you need something with “seamless” travel, regular independent levels are fine.