Non-invasively focusing light into strongly scattering media, such as biological tissue, is
highly desirable but challenging. Recently, wavefront-shaping technologies guided by
ultrasonic encoding or photoacoustic sensing have been developed to address this
limitation.
This technology has the potential
to provide highly confined strong optical focus deep in tissue for microsurgery of
Parkinson’s disease and epilepsy or single-neuron imaging and optogenetic activation.