I was getting a shader crash with all 5.4.1 projects at first but after deleting the DerivedDataCache for the engine and verifying it let me create a new TPP project and open it. I then tried creating a new Lyra project for 5.4 and started getting the shader crashes again. I tried the bios edits mentioned in the other thread but it made my computer BSOD loop so I had to revert my settings.
I hope Epic can get a high end PC to test on some day because a lot of their games have had shader issues on my PC and now on 5.4 their entire engine does!