Character import from Adobe Fuse + Mixamo (Hands Problem)

It seems like your skeleton uses Twist Bones - that’s why the wrist is bent oddly. While the wrist bone was likely not correctly re-targeted from the paragon character - and/or the settings for the retargeting of the bone are incorrect.

Rightclick Options, select show retargeting options, then select the wrist twist bone, and take another screenshot for us to see if that’s the case.